Customization: | Available |
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CAS No.: | 76144-81-5 |
Formula: | C6h14n2o2 |
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High Purity Chemical Mildronate / Kvaterin CAS 76144-81-5: Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meld onium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process.
High Purity Chemical Mildronate / Kvaterin CAS 76144-81-5
Product Name | Mildronate |
CAS NO. | 76144-81-5 |
Appearance | White powder |
Purity | 99% |
Storage | Keep in dark place,Sealed in dry,2-8°C |
Application&Usage |
In medicine, meld onium is principally used in the treatment of cardiac health issues. Doctors, particularly in Eastern Europe, use it to treat coronary heart disease. It is believed to help against angina and myocardial infarction, which many people know as heart attack. Heart problems can give rise to ischemia. This is a condition where insufficient amounts of blood flow to organs in the body, including the heart. Meld onium supposedly helps to dilate blood vessels to improve the flow of blood and oxygen. The drug alters pathways for carnitine through inhibition of the enzyme gamma-butyrobetaine dioxygenase (GBB). This reduces production of carnitine in the body, forcing the mitochondria to use glucose for energy generation. What this means is less oxidative stress and cellular damage than when reliance is on fatty acid beta oxidation. It is believed Mildronate lowers the levels of N-oxide, a carnitine breakdown product thought to contribute to atherosclerosis and congestive heart failure. It supposedly promoted peripheral circulation and exercise capability in a 2005 study when combined with lisinopril, a substance which inhibits angiotensin converting enzymes. The drug has been shown to be effective for treatment of acute ischemic stroke. It also appears to have anticonvulsants and antihypnotic benefits, making it potentially beneficial for seizure and alcohol intoxication treatments. Other conditions meld onium is used for include ocular ischemic syndrome and cerebral ischemia. |
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