| Customization: | Available |
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| CAS No.: | 439081-18-2 |
| Formula: | C24h25clfn5o3 |
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Chemical High Purity Anti-Cancer Drug Afatinib (BIBW 2992) CAS 439081-18-2 for Cancer Treatment : Afatinib is the first approved irreversible ErbB series blocker. The ErbB receptor family consists of 4 members: EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB4. ErbB family members communicate with other ErbB family members, and abnormal ErbB family signaling is a key driver of cancer cell growth and spread. Afatinib has two targets, EGFR and HER2, which can irreversibly block the mutation of epidermal growth receptor (EGFR) and the excessive performance of human epidermal receptor 2 (HER2) tyrosine kinase and stimulate abnormal internal information conduction in cells, permanently close the signaling channels on which cancer cells live, so that cancer cells cannot grow and reproduce, thereby treating cancer.
Chemical High Purity Anti-Cancer Drug Afatinib (BIBW 2992) CAS 439081-18-2 for Cancer Treatment
| Product Name | Afatinib |
| CAS NO. | 439081-18-2 |
| Appearance | White powder |
| Purity | 99% |
| Storage | Keep in dark place,Sealed in dry,2-8°C |
| Application&Usage |
1. Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth fector receptor 2 (Her2) and epidermal growth fector receptor (EGFR) kinases.
2. Afatinib is not only active against EGFR mutations targeted by first generation TKIs like erlotinib or gefitnib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.
3. Afatinib is a drug for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC).It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth fector receptor (EGFR) and erbB-2 (HER2).
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FAQ
Q1. What is about your company strength? A: Established in 2012, we have more than 8 years of experience in chemical industry.We can provide 10000+ kinds of API, intermediates, reagents & dyes, with high reputation in the industry. Q2. What's your MOQ? A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg. Q3. How do you treat quality complaint? A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss. Q4. What is about the delivery time? A: The goods of small quantity will be sent out in 3 working days. For bulk cargo, we will book the cargo space once the order is confirmed. Usually we will arrange the shipment in 7 -15 days. Q5. How about the packing? A: Usually we provide the packing as 25 kg/bag or carton. Powdered Packaging: 20/25kg/bag/ drum/can or according to client request. Liquid Packaging: 200-220kg drum or according to client request. Of course, if you have special requirements on them, we will according to you. Q6. What payment terms are acceptable? A: Trade assurance, T/T, Western Union, Money gram. PayPal, L/C, etc. Q7. Can you give me a discount price? A: S urely, it depends on your required quantity. Q8. Why I can not find the product I require in this shop? A: You can contact with us since we, Wuhan Lullaby supply comprehensive and series chemical intermediates and some other scientific & healthy materials, we didn't upload all our list on this site. |
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